Le Cléac'h, 39, from Brittany, crossed the finish line of the race in Les Sables d'Olonne, France, at 1537hrs UTC after 74 days, 3 hours, 35 minutes and 46 seconds at sea on his 60ft racing yacht Banque Populaire VIII.
His time sets a new record for the race, beating the previous record of 78 days 2 hours 16 minutes set by French sailor Francois Gabart in the 2012-13 edition by 3 days, 22 hours and 41 minutes.
Le Cléac'h, the runner-up in the 2008-09 and 2012-13 editions of the Vendée Globe, covered 24,499.52 nm at an average speed of 13.77 knots during the race, which began from Les Sables d'Olonne on November 6 last year.
The Vendée Globe, which was founded in 1989, follows the 'clipper route' around Africa's Cape of Good Hope, Australia's Cape Leeuwin and South America's Cape Horn.
Second-placed Alex Thomson is expected to cross the finish line on his boat Hugo Boss around 12 hours behind Le Cléac'h.
“My feeling is that this is a dream come true,” Le Cleac’h said. “I hoped to win this race 10 years ago but I finished second. Today is a perfect day. My team have been amazing they're the dream team, and this is their day too. I'm very happy for Alex, it's a great second place. It has been very difficult with him behind me, he gave me a really hard time in this Vendee Globe.”